基本信息:
邹振,男,博士,副教授,研究生导师。
邮箱:474779970@qq.com
个人简介:
2022年9月起加入yl34511线路中心国家杰青、教育部长江学者杨荣华教授团队从事科研教学工作。主要从事分子水平和纳米尺度上的化学生物分析与传感器研究。聚焦于核酸荧光传感与分子识别的关键科学问题,系统开展基于核酸的生化传感新原理与新方法的基础应用研究,构建疾病标志物分析、药物分析、环境污染检测、食品安全分析的新方法。目前主持承担国家自然科学基金青年项目、湖南省自然科学基金优秀青年项目、湖南省教育厅优秀青年项目、长沙市自然科学基金等多项研究课题。已在Angewandte Chemie、Biomaterials、Trends in Analytical Chemistry、Analytical Chemistry等国际权威期刊发表论文30余篇,申请发明专利8项,参编专著1部。湖南省研究生创新项目指导老师(3项)。与中南大学湘雅医院、湖南省肿瘤医院、湖南省人民医院等保持良好合作关系,针对临床问题展开科学研究,努力在分子诊断、疾病治疗等相关领域推进成果转化,产生效益。
主讲课程:
1.本科生课程:《分析化学》、《分析化学实验》、《化学信息学》
2.研究生课程:《科研方法与学术规范》
近年主持的科研项目:
1.湖南省自然科学基金优秀青年基金项目,2019JJ50653,高生物亲和性纳米诊疗体系的构建与应用,2022/01-2024/12,20万,主持
2.国家自然科学基金青年项目, 21705010,三链DNA编码的纳米孔技术用于肿瘤标志物的同步分析,2018/01-2020/12,25万,主持
3.湖南省教育厅优秀青年项目,20B032,三链核酸介导的双microRNA浓缩及其肿瘤协同治疗的研究,2020/09-2022/09,7万元,主持
4.湖南省自然科学基金青年基金项目,2019JJ50653,三链核酸框架纳米结构介导的microRNA靶向递送及肿瘤成像,2019/01-2021/12,5万,主持
5.国家自然科学基金重大研究计划培育项目, 91853104,p66Shc蛋白磷酸化调控肾小管上皮细胞凋亡通路的原位荧光分析,2019/01-2021/12,60万,参与
代表性论文:
(1)Zhen Zou, Libei He, Xiangxi Deng, Huangxiang Wang, Ziyun Huang, Qian Xue, Zhihe Qing*, Yanli Lei, Ronghua Yang,* Juewen Liu, Zn2+-coordination-driven RNA assembly with retained integrity and biological functions.Angewandte Chemie International Edition, 2021,60: 22970-22976.
(2)Zhen Zou, Xiaodou Liao, Le Yang, Ziyun Huang, Hua Yang, Qi Yan, Yufei Zhang, Zhihe Qing, Lihua Zhang, Feng Feng, Ronghua Yang*, Human serum albumin-occupying-based fluorescence turn-on analysis of antiepileptic drug tiagabine hydrochloride.Analytical Chemistry, 2020, 92(5): 3555-3562.
(3)Zhen Zou, Ziling Luo, Xuan Xu, Sheng Yang, Zhihe Qing, Juewen Liu, Ronghua Yang*, Photoactivatable fluorescent probes for spatiotemporal-controlled biosensing and imaging.TrAC Trends in Analytical Chemistry,2020, 125: 115811.
(4) Le Yang, Jin Zheng,Zhen Zou*, Haiyan Cai, Peng Qi, Zhihe Qing, Qi Yan, Liping Qiu, Weihong Tan, Ronghua Yang*, Human serum albumin as an intrinsic signal amplification amplifier for ultrasensitive assays of the prostate-specific antigen in human plasma.Chemical Communications, 2020, 56: 1843-1846.
(5)Zhen Zou, Hua Yang, Qi Yan, Peng Qi, Zhihe Qing, Jing Zheng, Xuan Xu, Lihua Zhang, Feng Feng,Ronghua Yang*,Synchronous screening of multiplexed biomarkers of Alzheimer's disease by a length-encoded aerolysin nanopore-integrated triple-helix molecular switch.Chemical Communications, 2019, 55: 6433-6436.
(6)Zhen Zou, Qi Yan, Sixin Ai, Peng Qi, Hua Yang, Yufei Zhang, Zhihe Qing, Lihua Zhang, Feng Feng, Ronghua Yang*,Real-time visualizing mitophagy-specific viscosity dynamic by mitochondria-anchored molecular rotor.Analytical Chemistry, 2019,91: 8574−8581.
(7)Zhen Zou, Peng Qi, Zhihe Qing, Jing Zheng, Sheng Yang, Weiju Chen, Ronghua Yang*,Technologies for analysis of circulating tumour DNA: Progress and promise.Trends in Analytical Chemistry, 2017, 97: 36-49.
(8)Zhen Zou, Dinggeng He, Linli Cai, Xiaoxiao He*, Kemin Wang*, Xue Yang, Liling Li, Siqi Li, Xiaoya Su,Alizarin complexone functionalized mesoporous silica nanoparticles: a smart system integrating glucose-responsive double-drugs release and real-time monitoring capabilities.ACS Applied Materials & Interfaces, 2016, 8: 8358-8366.
(9)Zhen Zou, Xiaoxiao He*, Dinggeng He, Kemin Wang*, Zhihe Qing, Xue Yang, Li Wen, Jun Xiong, Liling Li, Linli Cai,Programmed packaging of mesoporous silica nanocarriers for matrix metalloprotease 2-triggered tumor targeting and release.Biomaterials, 2015, 58:35-45.