基本信息(Basic Information)：

杨盛，籍贯湖南临澧，理学博士，教授，博士生导师，中国化学会高级会员，主要从事化学测量学-化学生物传感研究，期望发展适用于生物复杂体系和亚细胞层面的光学传感与生物成像新原理与新技术并应用于疾病精准诊断治疗、环境污染生物危害解析与预警、中药材功能鉴别与活性成分筛选。迄今已在Angew Chem Int Ed, Small, Anal Chem, ACS Sens等期刊发表第一/通讯作者论文30余篇，授权国家发明专利3项。先后主持承担国家自然科学基金3项。获2019年度湖南省自然科学一等奖（排名第2）。

联系方式(Contact Information)：

E-mail: yangsheng@hunnu.edu.cn

      WeChat                    QQ

工作及教育经历(Academic and Education Experiences)：

2024.01-至今，yl34511线路中心，yl34511线路中心，教授

            College of Chemistry and Chemical Engineering, Hunan Normal University, Professor

2022.09-2023.08，新加坡南洋理工大学，访问学者

             Nanyang Technological University, Singapore, Visiting Scholar (Supervisor: Prof. Bengang Xing)

2021.09-2023.12，yl34511线路中心，yl34511线路中心，副教授

             College of Chemistry and Chemical Engineering, Hunan Normal University, Associate Professor

2015.04-2021.08，长沙理工大学，化学与食品工程学院，讲师/副教授

             College of Chemistry and Food Engineering, Changsha University of Science and Technology, Assistant/Associate Professor

2010.09-2014.12，湖南大学，分析化学，博士

             Hunan University, Major: Analytical Chemistry, Ph.D. (Supervisor: Prof. Ronghua Yang)

2008.09-2010.09，湖南大学，有机化学， 硕士

             Hunan University, Major: Organic Chemistry, Postgraduate (Supervisor: Prof. Delie An)

2006.07-2007.08，上海睿智化学研究有限公司

             Shanghai ChemPartner Co., Itd.

2002.09-2006.06，湖南大学，化学， 本科

             Hunan University, Major: Chemistry, B.S.

研究兴趣(Research Interests)：

[1] 适用于复杂生物体系的荧光传感放大及高灵敏生物成像

    Biologically Compatible Activity-Based Fluorogenic Sensing and Amplification  for Sensitive Bioimaging  

[2] 多组分串联激活荧光传感与疾病精准诊断/污染危害解析

    Cascade Activity-Based Fluorogenic Sensing for Precise Disease Diagnosis and Pollution Hazard Analysis

[3] 亚细胞荧光传感与细胞器动态限域分析

    Subcellular Fluorescence Sensing for Organelle-Confined Dynamic Analysis

[4] 自噬相关生物传感与功能调控

    Autophagy Dependent Biosensing and Bioregulation

科研项目(Research Grants)：

[1] 国家自然科学基金面上项目（编号：22374044，资助期：2024.01-2027.12）

   National Natural Science Foundation of China (General Program, No: 22374044, 2024.01-2027.12)

[2] 国家自然科学基金面上项目（编号：21974013，资助期：2020.01-2023.12）

    National Natural Science Foundation of China (General Program, No: 21974013, 2020.01-2023.12)

[3] 国家自然科学基金青年项目（编号：21505006，资助期：2016.01-2018.12）

    National Natural Science Foundation of China (Young Program, No: 21505006, 2016.01-2018.12)

[4] 湖南省自然科学基金面上项目（编号：2022JJ30374，资助期：2022.01-2024.12）

    Hunan Provincial Natural Science Foundation of China (General Program, No: 2022JJ30374，2022.01-2024.12)

[5] 湖南省自然科学基金青年项目（编号：2017JJ3332，资助期：2017.01-2019.12）

    Hunan Provincial Natural Science Foundation of China (Young Program, No: 2017JJ3332，2017.01-2019.12)

[6] 湖南省教育厅科学研究优秀青年项目（编号：18B158，资助期：2018.09-2021.08）

    Scientific Research Fund of Hunan Provincial Education Department (Excellent Young Program, No: 18B158，2018.09-2021.08)

学术成果(Scholarly Works)：

全部论文参见以下网址（All the Publications are Listed in the Following Websites）：

https://www.webofscience.com/wos/author/record/591978

http://orcid.org/0000-0003-0867-6438

http://www.researchgate.net/profile/Sheng-Yang-13

代表性论文(Selected Publications)：

[1] Yibo Zhou*, Sheng Yang*, et al Integration of Hybridization Chain Reaction and Protein-Binding Amplification for Long-Term Imaging of Intracellular mRNA: Avoiding Signal Fluctuation, Analytical Chemistry, 2024, 96(19): 11061−11067

[2] Wenchao Lang, Sheng Yang*, Bengang Xing*, et al Enzyme-Responsive Fluorescent Labeling Strategy for In Vivo Imaging of Gut Bacteria, The Journal of Organic Chemistry, 2024, 89(20): 14641−14649

[3] Jingjing Li, Kai Zhang*, Sheng Yang*, et al Accelerated Activity-Based Sensing by Fluorogenic Reporter Engineering Enables to Rapidly Determine Unstable Analyte, Analytical Chemistry, 2024, 96(19): 7723−7729

[4] Yibo Zhou, Sheng Yang*, Zhihe Qing*, Ronghua Yang*, et al A Polymeric Nanobeacon for Monitoring the Fluctuation of Hydrogen Polysulfides During Fertilization and Embryonic Development, Angewandte Chemie International Edition, 2022, 61(16): e202114504

[5] Siya Chen, Sheng Yang*, Jing Zheng*, et al Design and Engineering of Hypoxia and Acidic pH Dual-Stimuli-Responsive Intelligent Fluorescent Nanoprobe for Precise Tumor Imaging, Small, 2021, 17(28): 2100243

[6] Xiao Liu, Sheng Yang*, Lin Yuan*, et al Dual-Stimulus Responsive Near-Infrared Reversible Ratiometric Fluorescent and Photoacoustic Probe for In Vivo Tumor Imaging, Analytical Chemistry, 2021, 93(13): 5420−5429

[7] Yibo Zhou, Sheng Yang*, Ronghua Yang*, et al Long-Lasting Bioluminescence Imaging of the Fibroblast Activation Protein by an Amphiphilic Block Copolymer-Based Probe, Analytical Chemistry, 2021, 93(8): 3726−3732

[8] Sheng Yang, Ronghua Yang*, et al Substrate-Photocaged Enzymatic Fluorogenic Probe Enabling Sequential Activation for Light-Controllable Monitoring of Intracellular Tyrosinase Activity, Analytical Chemistry, 2020, 92(10): 7194−7199